Observations
By Nestor Notabilis
- 16 minutes read - 3382 words
Preamble
Predictions is a big word, but it is not all speculation either.
(01/11) I settled on “Observations” instead.
A mix of rambling, anecdotal and factual content ahead.
SARS-CoV-2
Covid is going to continue to keep mutating and the more aggressively we vaccinate, the more aggressively it will try and figure out how to beat the vaccine.
My expectation is that it will continue to become more infectious but less lethal, albeit mortality risks are highly dependent on how healthy a person is and how strong their immune system is regardless of vaccination status.
Unless governments start accepting a sensible early treatment protocol, Covid will continue to come in seasonal waves. As more research comes out, I find myself agreeing with the theory that vitamin D has a lot of influence on how this seasonal wave impacts a society. Given the benefit of vitamin D on the immune system, I am inclined to extend that theory to other supplements that have equally proven beneficial for the human body.
Origin wise, my bet is still on the lab theory. No virus from nature has ever been this good at infecting ACE2 cells out of the box.
Papers
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency
https://www.nature.com/articles/s41423-021-00779-5
The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941658/
Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544107/
Seasonal UV exposure and vitamin D: Association with the dynamics of COVID-19 transmission in Europe
https://pubmed.ncbi.nlm.nih.gov/34608759/
Web
Genomic epidemiology of novel coronavirus
https://nextstrain.org/ncov/gisaid/global
The Last Post, Geert vanden Bossche (DVM, PHD)
https://www.geertvandenbossche.org/post/the-last-post
‘Leaky’ Vaccines Can Produce Stronger Versions of Viruses
How the coronavirus infects cells — and why Delta is so dangerous
https://www.nature.com/articles/d41586-021-02039-y
The Vaccines
Memetic Edition
“OSHA, WHO, and CDC are completely shifting policies for this vaccine on a Virus with a 99.67% survival rate while the makers have complete immunity from liability by congress."
“No vaccine is past stage III, has any long term data, was made in 1/6th of the time of the prior fastest vaccine, uses a technology that wasn’t approved for humans just last year, and is being given as the only option."
“Ivermectin meta-analysis shows a 77% cleanout rate of COVID as prophylaxis, costs next to nothing and has 40 years of testing on its side effects. The pandamic could be over in 3 weeks by deploying it. But yet its endlessly censored and told to be dangerous without reasoning. This is clearly some issue of the vested financial interests of the vaccine makers at a minimum."
“I’ll merely deploy an Ivermectin protocol and keep my vitamin D up in tandem with exercise after consulting a FLCCC medical professional."
Thanks Anon. Source
English Edition
A good vaccine takes 7 to 10 years to develop, so that is warning sign number one.
The vaccine technically works and is not without merit, it is the side effects you have to survive.
They do not limit transmission and spread, they do not prevent “breakthrough” cases.
The common cold belongs to the family of Coronavirus, while I have not been able to find a direct confirmation, I can remember an old medical text book that inferred influenza likewise to belong to the same family. (Yes, there is a difference between the two.)
Why is this fact important? To my knowledge, it is not possible to make a vaccine that can innoculate against a respiratory virus. I would posit, given the fact that, the flu vaccine is a yearly affair with an efficacy of 40% - 60%, I do not see any of the big pharma entities succeed at making a sterilizing Covid vaccine. Especially keeping in mind, that science has been trying to beat influenza since 1931, which at this point is far better understood than Covid.
Hence why for the foreseeable future we are dealing with a leaky vaccine, if we can even call it a vaccine. I would consider the mRNA variants experimental gene therapy at this point.
As per the above, if governments are not willing to look into effective early treatment they will continue to push the vaccine every 3 - 6 months until a point where too many people have been negatively impacted and the costs associated with such events keep mounting.
People will continue to believe the vaccine gives them superpowers, yet they are deeply afraid of unvaccinated people like its kryptonite to them. Vaccinated people do not seem to realize that, as every individual is on a different vaccination schedule, everyone’s vaccine-based immunity levels are going to be different. To the superpower crowd, your vaccinated friends may not be as safe to be around as you might think if you are that paranoid. Let us please avoid heralding in Apartheid.
Papers
The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines
https://www.biorxiv.org/content/10.1101/2021.08.22.457114v1
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70295-X/fulltext
Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3949410
On the Spike Protein
As it stands, the version 1.0 vaccines currently being used are tuned for Alpha Covid and make no sense for use with Delta roaming at large. Where it gets very interesting is how pharma decided to only use the spike protein as the reference to train the immune system on.
“The coronavirus genomes are the largest of the known RNA viruses (27 to 31.5 kb)" - Vijgen, Leen et al.
“Importantly, the genome size of the SARS-CoV-2 varies from 29.8 kb to 29.9 kb and its genome structure followed the specific gene characteristics to known CoVs;" - Khailany, Rozhgar A et al.
With the above in mind, the v1.0 vaccines only give you a partial download (mRNA set is 0.4 kb) of the ‘entirety’ that is the Coronavirus. To me this means the immune system is only trained on the spike protein but not everything else that is going through the process of mutation, leaving the body with poor defenses.
Is the spike protein toxic? My guess is that the effects of the spike protein are dangerous but not toxic. Graphene, if indeed present in the vaccine, makes me more worried as it actively fights for oxygen within your systems and has a known toxicology profile.
(2021/10/28) I stand corrected, the spike protein is a ball of fun. See Papers / Web Below.
Papers
On the Doctrine of Original Antigenic Sin
https://www.jstor.org/stable/985534
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902
Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?
https://pubmed.ncbi.nlm.nih.gov/34216962/
Web
Canceling the Spike Protein
http://www.orthomolecular.org/resources/omns/v17n24.shtml
Mass vaccination may permanently attenuate population-wide immunity to SARS-2
https://eugyppius.substack.com/p/mass-vaccination-may-permanently
Clearing up misinformation about the spike protein and COVID vaccines
https://joomi.substack.com/p/coming-soon
Pay no attention to the spike proteins behind the curtain
https://alexberenson.substack.com/p/pay-no-attention-to-the-spike-proteins
Short and Long term effects
Apart from the early reported incidents. I think we are going to see the first problems 6 - 12 months after a person’s vaccination cycle. Long-term implications span from 1 to 5 years in the form of reproductive issues and advanced aging problems due to telomere loss / shortening.
Very curious about the half-life for the Spike Protein and how that may impact effects.
Seems lipid nanoparticles really like ovaries, bone marrow and lymph nodes. First warning signs are already here with women reporting disturbances with their menstrual cycles. Make of that what you will.
Should ADE (See Below) become a thing, it means society will be at risk of outsourcing the functioning of their immune system to big pharma. I do not think that is a good idea. See also, “Marek’s disease”
Pregnancy
Pregnancy is a brutal and delicate process. There is a careful balance at play as new life is being created. In order not to upset that balance, for example:
- A lady should not smoke or drink alcohol
- Should consider changing dietary choices
- Stay away from certain house hold products / chemicals
- Stay away from cats. (Toxoplasma gondii)
- etc.
Likewise, pharmacautical drugs and antibiotics come with increased risk.
An mRNA vaccine that doesn’t have long term safety data, is totally fine of course as of this writing. Pregnant women are even considered a priority group at present.
Australia started vaccinating in earnest on the 22nd of February 2021.
New Zealand started vaccinating in earnest on the 20th of February 2021.
So I presume we will find out the first facts in early 2022.
Papers
A Review of Antibiotic Use in Pregnancy
https://pubmed.ncbi.nlm.nih.gov/26598097/
Association Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women
https://pubmed.ncbi.nlm.nih.gov/34251417/
Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study
https://pubmed.ncbi.nlm.nih.gov/33775692/
Accumulation of nanocarriers in the ovary: A neglected toxicity risk?
https://www.sciencedirect.com/science/article/abs/pii/S0168365912000892
Web
Drugs and pregnancy
https://www.thewomens.org.au/health-information/pregnancy-and-birth/pregnancy-drugs-alcohol/drugs/
Foods to eat or avoid when pregnant
COVID-19 Vaccination in Pregnant and Breastfeeding Women and those planning pregnancy
https://ranzcog.edu.au/statements-guidelines/covid-19-statement/covid-19-vaccination-information
The figures that show the real risk of Covid vaccine in pregnancy
https://www.conservativewoman.co.uk/the-figures-that-show-the-risk-of-covid-vaccine-in-pregnancy/
Pharma Responsibilities
Officially all major vaccines are on trial till 2023, despite their immediate government approvals.
Pfizer is not required to produce documentation on potential reproductive issues till 2025.
Papers
New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination
Injuries / Adverse Effects
I am reasonably convinced the numbers are higher then reported for injuries and adverse effects. Suggestions have been made for US data that a 20 - 60 multiplier should be considered.
More individual doctors are likely to come forward with ethical concerns.
I have heard little about human error during the vaccine administration process, if mRNA ends up straight in the bloodstream all manner of bad things can happen. I did come upon a paper confirming this possibility and fortunately the solution is easy.
“This study provided in vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk." - Li, Cal et all.
Web
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
(NN.: This one got a (((TEMPORARY REMOVAL))). So archive link.)
A Report on Myocarditis Adverse Events in the U.S. Vaccine Adverse Events Reporting System (VAERS) in Association with COVID-19 Injectable Biological Products
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483988/
Path Forwards
The vaccine is not entirely without merit, but with the current information it makes more sense to target the immunocompromised and people over the age of 60 as the risk of Covid for normal healthy humans is, by most accounts, on par with Influenza.
I am not convinced there is any merit for children to be vaccinated. Healthy growing bodies have a strong immune system, the next generation should be able to grow up with natural Covid defenses.
The benefits do not outweigh the costs.
Reading Material
Government
COVID-19 deaths by age group and sex
https://www.health.gov.au/resources/covid-19-deaths-by-age-group-and-sex
Provisional COVID-19 Deaths by Sex and Age
https://data.cdc.gov/NCHS/Provisional-COVID-19-Deaths-by-Sex-and-Age/9bhg-hcku
Papers
No Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Groups Infected with SARS-CoV-2 Delta Variant
https://www.medrxiv.org/content/10.1101/2021.09.28.21264262v1
Shedding of Infectious SARS-CoV-2 Despite Vaccination
https://www.medrxiv.org/content/10.1101/2021.07.31.21261387v5
Genomic characterization of a novel SARS-CoV-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161481/
Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544107/
Toxicology of Graphene-Based Nanomaterials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039077/
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors
https://pubmed.ncbi.nlm.nih.gov/34200325/
SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354225/
Why are we vaccinating children against COVID-19?
https://www.sciencedirect.com/science/article/pii/S221475002100161X
Web
Influenza Vaccine
https://en.wikipedia.org/wiki/Influenza_vaccine
How effective are flu vaccines?
https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm
Menstrual changes after covid-19 vaccination, “A link is plausible and should be investigated”
https://www.bmj.com/content/374/bmj.n2211
Assessing the Safety of COVID-19 Vaccines: A Primer
https://link.springer.com/article/10.1007/s40264-020-01002-6
Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine
https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/
Exploring the Supply Chain of the Pfizer/BioNTech and Moderna COVID-19 vaccines
Anthrax and Gulf War Illness (GWI): Evidence for the Presence of Harmful Anthrax Antigen PA63 In the Serum of Veterans with GWI
(NN.: Provided as an historical example, make your own conclusions.)
Ivermectin
Cheap and very safe all things considered.
Plenty of compelling proof out there showing the potential in combination with other compounds. If only governments would have a look at other parts of the world.
I expect it to become a staple when pharma can no longer control the narrative surrounding it. Likewise, continue to expect delays in favourable Ivermectin papers being published in the interim.
Alternatively, it is pushed to complete irrelevance when Pfizer’s “PF-07321332” comes out, which supposedly has ‘similar’ protease-inhibiting properties. Then the narrative can be spun saying “See we do not need Ivermectin, we have something better”. I am doubtful at this point if it will be just as effective but the more treatment options the better in the big picture.
I hope Professor Borody gets his moment in the spotlight.
Papers
Ivermectin papers and meta analysis
Medical safety of Ivermectin, Professor Jacques Descotes
https://www.medincell.com/ivermectin/
Web
(2021) Ivermectin Toxicity Review, Chris Martenson
https://www.youtube.com/watch?v=ATiX0-2PEr4
Ivermectin Triple Therapy Protocol for COVID-19 Released to Australian GPs for Infected Elderly and Frontline Workers
Molnupiravir
Expensive and a questionable safety profile.
I would expect this to be taken out of the treatment schedule as soon as possible should Ivermectin get approval.
Trivia: Molnupiravir’s progenitor (EIDD-1931), began its life as research for treating the Venezuelan equine encephalitis virus (VEEV). Horse jokes anyone ?
“These results indicate highly active mutagenic ribonucleosides may hold risk for the host." - Zhou, Shuntai et al.
Papers
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template
https://www.jbc.org/article/S0021-9258(21)00563-9/fulltext
β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells
https://pubmed.ncbi.nlm.nih.gov/33961695/
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template
https://pubmed.ncbi.nlm.nih.gov/33989635/
Web
Molnupiravir: Covid Wonder Drug or Money-Making Scam?
https://off-guardian.org/2021/10/28/molnupiravir-covid-wonder-drug-or-money-making-scam/
Merck Ignores Molnupiravir Cytotoxicity
https://defyccc.com/merck-ignores-molnupiravir-cytotoxicity/
Ridgeback/Merck’s molnupiravir for Covid-19 has MOA, administration advantages but Phase IIa faces execution obstacles, may have value gaps
Early safety concerns accompanied Merck’s molnupiravir, the first potential oral COVID-19 therapy
Two Indian drugmakers to end trials of generic Merck pill for moderate COVID-19
Merck Sells Covid Pill for 40 Times What It Costs to Make
https://theintercept.com/2021/10/05/covid-pill-drug-pricing-merck-ridgeback/
Remdesivir
(Very) Expensive and a questionable safety profile.
I would expect this to be taken out of the treatment schedule as soon as possible should Ivermectin get approval.
Papers
Remdesivir and Acute Renal Failure: A Potential Safety Signal From Disproportionality Analysis of the WHO Safety Database
https://pubmed.ncbi.nlm.nih.gov/33340409/
Efficacy and safety of remdesivir in hospitalised COVID-19 patients: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/34331674/
(Vaccine) Antibody-Dependent Enhancement (ADE / VADE)
Do not take my word for it (go ask the internet), better explained by other sources but here is my TL;DR; on it.
ADE happens when the immune system ‘forgets’ what kinds of antibodies it keeps in stock to fight infections. The net result of this is, that when the body forgets what Covid should be after having been vaccinated, getting infected by actual Covid can result in a far more severe case.
(2021/10/27) Learned that those same anti-bodies that have ‘forgotten’ how to fight for you can also aid in making infection easier for an incoming virus.
“Previous respiratory syncytial virus and dengue virus vaccine studies revealed human clinical safety risks related to ADE, resulting in failed vaccine trials." - Lee, Wen Shi et al.
Papers
A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
https://journals.sagepub.com/doi/10.1177/20587384211050199
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
https://pubmed.ncbi.nlm.nih.gov/33113270/
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
https://pubmed.ncbi.nlm.nih.gov/32908214/
Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?
https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext
“Smart” People
Smart people are going to continue to fight each other about how statistics should be interpreted and how their interpretation is better to prove their respective point. I am more concerned with the alarm bells that no one is hearing despite all the smart people saying “reporting databases are not entirely accurate so we only use them for signals”.
It doesn’t help that definitions have changed a lot, if people die “from” Covid or “with” Covid and “patient was partially fully vaccinated but not fully vaccinated and died after having been only fully partially vaccinated”.
Don’t see this situation resolving itself anytime soon.
(20/10) Going to do a ‘Called it’, see link.
Web
Confirmation of Vaccine-Associated Mortality
https://roundingtheearth.substack.com/p/confirmation-of-vaccine-associated
Winter is Coming
I am expecting the word “Twindemic” to become a thing as the regular old Flu / Influenza has (((suddenly))) re-appeared after having been ‘dormant’ for the past 2 years.
England is now already reporting #WorstFluEver. Symptoms that are not quite Covid but Covid-like.
The United States started vaccination in their summer and for many people the vaccine efficacy should be wearing down now with Winter around the corner. So if Influenza has returned and people have a false sense of security it is going to make for one hell of a double whammy.
Meanwhile, for the southern hemisphere where summer is just starting we will know what we are in for next year when winter comes again.
Governments
For a representative, I can appreciate that when you take office you were not expecting to deal with a pandemic of this magnitude. You go in, make your showreel, take some flak and move to a nicer job when done.
Having said that, as long as everyone of you keep going with a reactive response rather then a proactive response, this is only going to continue to drag on.
The mental health of the populace is declining, this has many deleterious effects that cannot be discounted in the big picture.
New Zealand
Is woefully underprepared at this point. Despite efforts to increase vaccination rates little has been done to expand / improve the hospital system.
No early treatment advisory.
Still not a peep about encouraging people to have some Vitamin D, which is looking to become an important factor to consider in case outcomes.
Remdesivir for in-hospital treatment…
The entire strategy is based on nothing but vaccines and goal post moving.
Government Guidance
Interim Guidance - Clinical Management of COVID-19 in Adults
Press
‘Technical anomaly’ spurs urgent law change for Covid-19 vaccine
Australia
New South Wales is going to be the litmus test if it is in fact possible to open international borders. I remain skeptical that this ends well, as at this point the government continues to push economical priorities over population safety.
I reason that the large outbreaks in New South Wales and Victoria can be partly attributed to population density in the major cities of Sydney and Melbourne respectively.
No early treatment advisory.
Still not a peep about encouraging people to have some Vitamin D, which is looking to become an important factor to consider in case outcomes.
Remdesivir for in-hospital treatment…
Official advice is: If you get Covid, stay at home, do not call the hospital unless it gets very bad. Treatment that late likely means being put on a ventilator and a hail mary under the current protocol. Unnecessary Covid deaths will continue.
The entire strategy is based on nothing but vaccines and goal-post moving.
The Narrative and The Media
We are living in an extraordinarily weird time when anonymous internet commentators have more freedom of expression on medical matters than a trained professional. Good doctors demoralised by this state of affairs, will be going for early retirement as the state continues to interfere with how they should practise medicine when they know what is best for their patients.
I fully expect the technology oligarchy, that has no medical training whatsoever, will continue their censorship to keep the narrative on course. The only thing that may have some effect is if people stop using social media en-masse, but people are addicted to their dopamine.
Tinfoil hat time: When control of the narrative becomes too difficult we will see the “Cyber Pandemic” happening. The seeds have already been planted just like “Event 201” which we are experiencing now.
“Safe and Effective”
“Imma let you finish but the government had the best memes of all time. One of the best memes of all time!"
Web
The Covid World