Supplement Stack
By Nestor Notabilis
- 18 minutes read - 3627 words
Preamble
This is a living document initially publised on the 17th of October, the publication date shown reflects the latest update.
What follows is an overview of what might make a good combination of supplements that will allow an individual to “prepare their terrain” and mount a good defense in case of a Covid infection. This should not be taken as medical advice and is provided for education value. You should do your own homework, and consult with your physician as to what supplement levels are appropriate for your geographical presence, wellbeing, lifestyle, gender and choice of diet.
In theory, the supplements proposed carry little risk to the individual based on well established track records, more often than not, spanning decades.
That said, I am not a physician and the internet is not always truthful. Basing medical decisions on the meandering of a random stranger should be done with great care. See the Disclaimer.
I have compiled the following based on various discussions, articles and videos. There is little original thought here and I do not claim there to be. Links will be provided in a best-effort manner.
Use your search engine and broaden your mind or start your journey here: https://c19early.com/
Read to the end, nothing is without a degree of risk (even if you consider them small).
“We have been brainwashed into thinking vitamins are no big deal, they are dangerous, they are chemicals, they will mess you up if you don’t know what you are doing with them." - Dr. Stasha Gominak
The Stack
Budget Edition
In discussions, the idea of a budget stack was raised for government rollout use, low income families and those averse to having to take a high number of pills. The following, combined with a healthy diet, is offered for consideration.
| Supplement | Amount | When | Upper Limit | Notes |
|---|---|---|---|---|
| Vitamin C | 500 - 1000mg | M/E | 3000mg | (Twice, Daily) |
| Vitamin D | 5000 - 10,000IU | L | 10000IU (ES) | Take with care. |
| Vitamin K | 100 - 200mcg | L | ||
| Zinc | 25 - 45mg | E | 50mg | Take with care. |
M: Morning | L: Lunch | E: Evening | ES: Endocrine Society
The Works
| Supplement | Amount | When | Upper Limit | Notes |
|---|---|---|---|---|
| Vitamin C | 500 - 1000mg | M/E | 3000mg | (Twice, Daily) |
| Vitamin D | 5000 - 10,000IU | L | 10000IU (ES) | Take with care. |
| Vitamin K | 100 - 200mcg | L | ||
| Magnesium | 400mg | L | 1000mg | |
| Zinc | 25 - 45mg | E | 50mg | Take with care. |
| Selenium | 100mcg | M | 400mcg | Take with care. |
| NAC | 500 - 1000mg | M/L | 1800mg | |
| Glutathione | 500mg | L/E | 1400mg | |
| Quercetin | 1000mg | E | 1500mg | |
| Natto Serra | - | E | See Below. |
M: Morning | L: Lunch | E: Evening | ES: Endocrine Society
Bonus Supplements
| Supplement | Amount | Upper Limit | Notes |
|---|---|---|---|
| L-Lysine | 1000mg | 8000mg | |
| PQQ | 10mg | 20mg | |
| CoQ-10 | 200mg | 600mg | |
| Melatonin | 10mg | 12mg | See Below. |
Pending Supplements
| Supplement | Amount | Upper Limit | Notes |
|---|---|---|---|
| Vitamin B | - | - | - |
| Niacin | - | - | - |
| Tryptophan | - | - | - |
| L-arginine | - | - | - |
TL;DR;
(NN.: Everything you could possibly want to know with 300+ citations.)
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy
https://www.sciencedirect.com/science/article/pii/S0223523422000770
My result
I started my personal research into Covid-19 in April 2021 and compiled this supplement stack early on. I proceeded to have bloodwork done first and discussed the results and research with my physician. In short, while my physician could not comment on the efficacy of preventing Covid-19 with this stack, the general consensus was it should give a healthy boost to the immune system related functions of the body. As long as upper limits are not exceeded any (long-term) harm should be non-existent or be minimal.
Cleared for experimentation, I have been taking the following over the past 6 months. Overall I have regular sleep, apppetite is normal, energy levels are good. No issues with finishing sets and reps at the gym. (Every other day is gym day.)
February 2022
I am perfectly fine, despite supplementing with what would be considered to be high dosage levels now 8 months on. My December ‘21 medical results certify me as being a “healthy human” within known clinical benchmarks. Vitamin D levels > 130nmol/L.
Moved Magnesium to Lunch time, Zinc to Evening. Seems to assist in sleep initiation.
Theory
There is still much debate on how effective and safe the current available vaccines are. In the spirit of “preparing your terrain”, a supplement stack is a relatively safe way to improve the chances of dealing with Covid and minimizing potential harm from the vaccine. It may take 7 - 10 days before the benefits of supplementation start to show.
If you have been asked (((coerced))) to have the vaccine, start with this stack atleast 2 weeks beforehand and continue afterwards, try to stay home 2 weeks afterwards as well, this should in theory minimize any happenstances. You will be most at risk from Covid in the days immediately after vaccination.
There is a lot of emphasis on supplements that aid cardiovascular health. My reasoning here is, that Covid starts as a respiratory virus and as it settles in becomes a cardiovascular problem. In particular, spike proteins causing micro-clotting in lung and brain capillaries and untreatable heart damage.
Again, I am not a medical professional, I just follow the data. Seek professional guidance.
Protip: If you are male and a fan of pornography, keep in mind that when you discharge your energy constantly, you are draining your body of important trace minerals that are of vital importance to your immune system and bodily health. (NoFap is not entirely a meme.)
Papers
Early effectiveness of COVID-19 vaccination with BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector vaccine on symptomatic disease, hospitalisations and mortality in older adults in England
https://www.medrxiv.org/content/medrxiv/early/2021/03/02/2021.03.01.21252652.full.pdf https://www.medrxiv.org/content/10.1101/2021.03.01.21252652v1
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
https://www.nature.com/articles/s41569-020-0413-9
Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750357/
Role of vitamins and minerals as immunity boosters in COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190991/
A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients
https://www.medrxiv.org/content/10.1101/2020.06.01.20112334v2
On Ivermectin
I am confident that Ivermectin has multiple beneficial properties at this point in time. Unfortunately it has become unobtainium in Australia and New Zealand through legitimate methods. I hope the narrative surrounding it changes in the short term, as right now any discussion is quickly shut down.
Australian Professor Borody released a treatment protocol in August 2020, however this has gotten very little discussion in the mainstream press or government departments.
I may collate more information on Ivermectin at a later point in time. For now I want to focus on readily available options on this side of the globe.
Papers
Ivermectin papers and meta analysis
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
https://www.sciencedirect.com/science/article/pii/S2052297521000883
Web
Ivermectin Triple Therapy Protocol for COVID-19 Released to Australian GPs for Infected Elderly and Frontline Workers
On Alternatives
This is still what I would consider “early days” but the suggestion has been made that the following may have similar helpful effects.
Papers
The Paradox of the Low Prevalence of Current Smokers Among COVID-19 Patients Hospitalized in Nonintensive Care Wards: Results From an Italian Multicenter Case–Control Study
https://academic.oup.com/ntr/article/23/8/1436/5910167
Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease?
https://pubmed.ncbi.nlm.nih.gov/11246702/
Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248381/
Cannabidiol induced apoptosis in human monocytes through mitochondrial permeability transition pore-mediated ROS production
https://pubmed.ncbi.nlm.nih.gov/29940353/
Hydration and Sleep
Drink enough water, you probably aren’t drinking enough anyway.
Get enough Sleep, the body needs downtime to do maintenance.
Papers
Water, Hydration and Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908954/
Sleep and immune function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256323/
Sleep and Metabolism: An Overview
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929498/
The Stack, in Detail
Vitamin B
Work in progress, promising early indications.
Papers
Be well: A potential role for vitamin B in COVID-19
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7428453/
Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8242279/
Web
The Role of Thiamin in High Calorie Malnutrition
https://austinpublishinggroup.com/nutrition-food-sciences/fulltext/ajnfs-v3-id1061.php
Vitamin C
Somewhere along the evolutionary path we lost the ability to synthesize Vitamin C in our own body so the human body is dependent on it from external sources.
While more expensive, have a look at Liposomal Vitamin C rather then the usual pill form as it offers a better absorption ratio.
“It is important to remember that preventing and treating respiratory infections with large amounts of vitamin C is well established. Those who believe that vitamin C generally has merit, but massive doses are ineffective or somehow harmful, will do well to read the original papers for themselves." - Andrew W. Saul, first paper cited below.
Class
Immune System, Oxidative Stress
Side Effects
Primarily abdominal cramps if too high a dosage is consumed and usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Papers
Vitamin C Protects Against Coronavirus
http://orthomolecular.org/resources/omns/v16n04.shtml
Papers (Interesting)
Vitamin C, Pain and Opioid Use Disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572147/
Ascorbic acid (vitamin C) effects on withdrawal syndrome of heroin abusers
https://pubmed.ncbi.nlm.nih.gov/10836211/
Video
(2015) Lecture on Vitamin C, by Suzanne Humphries
https://www.youtube.com/watch?v=y0LLX0sgwAU
(2010) NZ Farmer Beats Swine Flu With Vitamin C
https://www.youtube.com/watch?v=GApXBaZuw14
Vitamin D
Also known as “The Sunshine Vitamin” its use by the human body falls into many broad categories. If you primarily work in office environments or at home you are likely Vitamin D deficient.
Considerations
Vitamin D is technically a hormone and builds up over time. The idea being that humans are engineered to bank your Vitamin D during summer for use in winter. As such, it can take months to up your levels if they are deficient. Daily supplementation intake appears to the favoured approach vs weekly dosage.
Vitamin D is best taken in the morning or at lunch time with food. Taking Vitamin D at night may disrupt your sleep in various ways.
General consensus is that 5000IU is a “safe” dose in tandem with Vitamin K2 for absorption. If you intend to take 10,000 IU on a daily basis it is advised to have regular blood screening done to evaluate your levels.
For Australia and New Zealand the “sufficient and average” level is considered at 50 - 60 nmol/L (20 - 24 ng/ml). Research is suggesting optimal levels are >100nmol/L (40ng/ml). With what I have been reading though, a person who spends all their time outside (ie. outdoor athlete, beach life saver) will be at a comfortable 125nmol/L (50ng/ml). Seeing as Vitamin D production is self limiting under natural circumstances I am inclined to believe this may be the ideal number for a healthy human being.
“However, superior benefits are observed at even greater levels. For example, only at 25(OH)D levels >40 ng/mL, does vitamin D begin to be stored in the muscle and fat for future use." - Ogan, D., & Pritchett, K. (2013).
Class
Immune System, Bone, Muscles, Weight Management
Side Effects
If too high a dosage is taken Vitamin D toxicity occurs with the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
If left untreated, buildup of calcium in blood (hypercalcemia), bone and kidney problems.
Papers
(NN.: Highly recommended read. Covers more then just Covid.)
A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency
https://www.frontiersin.org/articles/10.3389/fpubh.2020.00513/full
Vitamin D and the Athlete: Risks, Recommendations, and Benefits
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3725481/
Monthly high-dose vitamin D3 supplementation and self-reported adverse events in a 4-year randomized controlled trial
https://www.clinicalnutritionjournal.com/article/S0261-5614(18)31248-2/fulltext
COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis
https://www.medrxiv.org/content/10.1101/2021.09.22.21263977v1
Web
The Vitamin D Wiki
https://vitamindwiki.com/VitaminDWiki
The importance of Vitamin D for Athletes
(NN.: Amazing article by Heather Heying, co-host of the Darkhorse Podcast.)
Vitamin D Deficiency and Covid-19: Make D While the Sun Shines (And when the sun doesn’t shine, supplement)
https://naturalselections.substack.com/p/vitamind
Roll Call of Credible Experts Advocating Vitamin D for COVID-19
https://vitamindforall.org/rollcall.html
Videos
High Intensity Health: Vitamin D, Deep sleep & Gut Bacteria w/ Dr. Stasha Gominak
https://www.youtube.com/watch?v=74F22bjBmqE
Vitamin K
My best interpretation is that Vitamin K is “glue”. Being responsible for binding calcium to bones and is thus important for bone health. It is also suggested that Vitamin K helps Vitamin D absorption thus lowering toxicity risks.
Class
Immune System, Bone, Cardiovascular, Brain
Side Effects
There is no specified Upper Intake Level from what I could find. Any deleterious effects are rare or happen in combination with other specific medicine.
Papers
Vitamin D toxicity redefined: Vitamin K and the molecular mechanism
https://www.sciencedirect.com/science/article/abs/pii/S0306987706007171
Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019
https://pubmed.ncbi.nlm.nih.gov/33023681/
Magnesium
Magnesium is an important trace mineral that seems to have broad applicability in order to achieve optimal health. From what I understand many bodily sub-systems utilize Magnesium and it is worth reading up on.
While there are multiple varieties available, consensus among my peers is that Magnesium Glycinate offers the best benefits. In particular in regards to sleep and anti-inflammatory properties. Remember to do your homework.
Side Effects
If too high a dosage is consumed, the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Class
Immune System, Bone, Skin, Cardiovascular, Brain, Sleep, PMS
Papers
Populations in Low-Magnesium Areas Were Associated with Higher Risk of Infection in COVID-19’s Early Transmission: A Nationwide Retrospective Cohort Study in the United States
https://www.mdpi.com/2072-6643/14/4/909
Possible roles of magnesium on the immune system
https://pubmed.ncbi.nlm.nih.gov/14506478/
Zinc
Zinc is an important trace mineral that, much like Magnesium, seems to have broad applicability in order to achieve optimal health.
While a little more expensive, Zinc Picolinate is considered to have the best absorption rate.
Class
Immune system, Vision, Cardiovascular, Testosterone
Side Effects
Do not go above the Upper Intake Level of 50mg, prolonged high dosage may cause copper (and other trace mineral) absorption issues.
Some people may experience an allergic reaction.
Papers
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7365891/
Zinc for the prevention and treatment of SARS-CoV-2 and other acute viral respiratory infections: a rapid review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395818/
Zinc 2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro
https://pubmed.ncbi.nlm.nih.gov/34514483/
COVID-19: Poor outcomes in patients with zinc deficiency
https://pubmed.ncbi.nlm.nih.gov/32920234/
Selenium
Selenium is a trace mineral not produced by the body and is found in foods such as Brazil nuts and sunflower seeds. It is suggested to have anti-inflammatory and anti-oxidative properties and helps the immune system much like Zinc does.
Some parts of the world are more bountiful in Selenium than others, so you may already receive enough from your diet. You may or may not need this supplement.
Class
Immune System, Thyroid Health, Mineral Processing
Side Effects
Like Zinc, do not exceed the upper limit.
If too high a dosage is consumed, the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Papers
Selenium supplementation in the prevention of coronavirus infections (COVID-19)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246001/
Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937041/
Web
Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults
https://www.sciencedirect.com/science/article/pii/S0261561415003404
N-acetylcysteine (NAC)
NAC is an amino acid that assists in the production of Glutathione. It is popular amongst fitness people to improve performance and recovery. Early research shows it may be beneficial for compulsive and bipolar disorders.
It is also suggested that NAC, as the precursor to Glutathione, is helpful as a detox protocol for Graphene Oxide.
Class
Immune System, Free Radicals, Anti-Inflammatory, Cardiovascular, Brain
Side Effects
If too high a dosage is consumed, the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Special Note
Depending on the vendor the following notice may or may not be present on the label, bottle or bag:
“Prolonged or elevated intake may alter liver function tests. Inform your physician that you are ingesting NAC if you undergo liver function tests. If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.”
Legal Status
Acetylcysteine was discovered in the early 60’s and had little to no restrictions. In America however, the FDA banned the sale of NAC as a supplement as per July 2020. It is suggested this was due to the emergency authorisation for the initial vaccines, and NAC was considered a “cure for Covid.”
Thankfully the rest of the world did not follow this same path.
Papers
Therapeutic potential of N-acetyl cysteine (NAC) in preventing cytokine storm in COVID-19: review of current evidence
https://pubmed.ncbi.nlm.nih.gov/33829465/
Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radical scavenger
https://pubmed.ncbi.nlm.nih.gov/30892320/
Videos
MedCram: “NAC” Supplementation and COVID-19 (N-Acetylcysteine)
https://www.youtube.com/watch?v=Dr_6w-WPr0w
Glutathione
Copying from Wikipedia: “Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals.”
Also, it appears Mitochondria like Glutathione, healthy Mitochondria go a long way for optimum health.
Tip: “Glutathione is one of the major antioxidants present in the lung."
Protip: Paracetamol depletes Glutathione stores. Paracetamol would be a very bad idea when you have contracted Covid.
Class
Free Radicals, Antioxidant, Cardiovascular
Side Effects
Some people may experience an allergic reaction.
Papers
The Effect of Glutamine Supplementation on Serum Levels of Some Inflammatory Factors, Oxidative Stress, and Appetite in COVID-19 Patients: A Case-Control Study
https://www.researchsquare.com/article/rs-748690/v1
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19
https://www.nature.com/articles/s41418-021-00892-y
The impact of therapeutic doses of paracetamol on serum total antioxidant capacity
https://pubmed.ncbi.nlm.nih.gov/12911681/
Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263077/
Web
Glutathione: the Detox Antioxidant
https://paleoleap.com/glutathione-the-detox-antioxidant/
Videos
MedCram: Glutathione Deficiency, Oxidative Stress, and COVID 19
https://www.youtube.com/watch?v=OtL0B1bqXak
Quercetin
Quercetin, and by that extent Bromelain, have seen little research but it is accepted to have antioxidative properties and good for heart health.
Class
Immune system, Free Radical Scavenger, Cardiovascular
Side Effects
Some people may experience an allergic reaction.
Papers
Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein
https://pubmed.ncbi.nlm.nih.gov/33635001/
Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2
https://bjbas.springeropen.com/articles/10.1186/s43088-021-00107-w
Oral Quercetin in Adult Patients as a Potential Nutraceutical against Coronavirus Disease 2019 (COVID-19)
https://journaljamps.com/index.php/JAMPS/article/view/30222
Nattokinase / Serropeptase
Nattokinase is considered a cardiovascular folk remedy in Japan. Serropeptase is considered beneficial for pain and inflammation.
Class
Anti-Inflammation / Body Clean Up
Side Effects
Considered “Safe”.
May lower blood pressure, suggestions are made to stop taking at least 2 weeks before having surgery.
Papers
Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265778/
Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/
Bonus Round
The following are for the supplement Connoisseur. If you have gotten this far, you probably already have some idea of the benefits have can offer.
Melatonin
The sandman hormone released by the pineal gland. Important for our circadian rhythnm and early research is showing immune system and antioxidant properties. Following this one with great interest.
Class
Immune System, Antioxidant, Sleep
Side Effects
Considered “Relatively Safe”
Should be taken with care as it may disrupt natural melatonin production over time if taken consistently. Causes drowsiness at higher doses, thus best taken before going to bed.
Papers
Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551551/
Melatonin as an antioxidant: under promises but over delivers
https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12360
Melatonin and its influence on immune system
https://pubmed.ncbi.nlm.nih.gov/18212405/
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12267
COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor
https://pubmed.ncbi.nlm.nih.gov/32922174/
Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8190272/
Web
Melatonin Research
https://www.melatonin-research.net/
Melatonin in Inflammation, Autoimmune Diseases & Immunity
https://selfhacked.com/blog/melatonin-th1-th2-inflammation-autoimmune-diseases/
Melatonin improves sleep, & sleep is valuable
https://www.gwern.net/Melatonin
Videos
Dr. Richard Neel’s presentation: May 10, 2021 High Dose Melatonin
https://www.youtube.com/watch?v=oFsjVH596W0
MedCram: Insomnia Explained Clearly - Causes, Pathophysiology & Treatment
https://www.youtube.com/watch?v=vdc8JonEax8
PQQ / CoQ-10
Pyrroloquinoline quinone (PQQ), is consider the “longevity vitamin” and there is still much debate about its requirement in the human body.
Coenzyme Q10, is often touted for its anti-inflammatory properties. I got it recommended for cardiovascular health and its free radical scavenging powers.
Side Effects
PQQ has little data.
For COQ-10, if too high a dosage is consumed, the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Class
Cardiovascular, Energy, Oxidation, Bad-LDL
Papers
Recent progress in studies on the health benefits of pyrroloquinoline quinone
https://pubmed.ncbi.nlm.nih.gov/26168402/
Coenzyme Q10 Supplementation in Aging and Disease
https://pubmed.ncbi.nlm.nih.gov/29459830/
L-Lysine
Most bottles will say “Essential Amino Acid”. I’ve been taking L-Lysine on the premise of keeping my eyes healthy. There are claims that it can prevent or delay the onset of cataracts. There are early indications that it may also be beneficial for overall health and the immune system.
Class
Immune System, Collagen, Metabolism, Pre-Carnitine
Side Effects
Some people may experience an allergic reaction.
If too high a dosage is consumed, the usual suspects. (Diarrhea, Nausea, Vomiting, Heartburn, Headache, Insomnia.)
Papers
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection
https://pubmed.ncbi.nlm.nih.gov/34372507/
Web
L-Lysine: Benefits, the Right Dosage, and Warnings
https://1md.org/health-guide/immunity/ingredients/immune-l-lysine
4 Impressive Health Benefits of Lysine
https://www.healthline.com/nutrition/lysine-benefits
Limitations
The Papers and Web links provided are put here on a best effort basis. The papers in particular, are a mix of preprint and well cited ones. At times they are picked on a “sounds logical and sensible” approach or having been provided a link on referral.
Acknowledgements
With much appreciation to the work of Chris Martenson, Covid19Crusher and various other Internet sources and discussions.
To the Anon’s out there who helped, thank you.
What now?
Do your homework, make a list, visit your physician, discuss what is appropriate for your body.
Take a moment to read my Disclaimer.